A Microfabricated Dielectric Affinity Sensor for Continuous Glucose Monitoring
نویسندگان
چکیده
We present a microfabricated affinity sensor using permittivity measurement for continuous glucose monitoring (CGM). This device is based on a perforated electrode separated from a bottom electrode on a substrate by a solution of a synthetic glucose-sensitive polymer. Glucose permeates through the perforated electrode and binds with the polymer, leading to a change in the polymer solution permittivity, which can be measured via the sensor capacitance. We characterize the frequency-dependent glucose response of the sensor capacitance, and assess the time response and the drift of the device. This glucose sensor has potential use in implantable, long-term, and continuous glucose monitoring.
منابع مشابه
Continuous monitoring of glucose in subcutaneous tissue using microfabricated differential affinity sensors.
OBJECTIVE We describe miniaturized differential glucose sensors based on affinity binding between glucose and a synthetic polymer. The sensors possess excellent resistance to environmental disturbances and can potentially allow wireless measurements of glucose concentrations within interstitial fluid in subcutaneous tissue for long-term, stable continuous glucose monitoring (CGM). METHODS The...
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